Monday, June 17, 2019

New drug could help treat neonatal seizures

A new drug that inhibits infant seizures in placental mammal models might open up new avenues for the treatment of brain disease in human newborns. Researchers have known that gluconate a little compound found in fruit associated honey acts as a medicine, inhibiting seizures by targeting the activity of channels that manage the flow of chloride ions in and out of infant neurons.

Over the past decades, many drugs have been developed to treat epilepsy in adults. However, neonatal epilepsy patients are often resistant to or do not respond to current anti-epilepsy drugs, and long-term use of some of these treatments may have side effects on brain development.

Gluconate can inhibit seizure activity in neonatal neurons. More importantly, gluconate suppresses seizure activity in neonatal animals more effectively than in adults.
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Gluconate is already widely used in the food and pharmaceutical industries as an inactive food or drug additive. For example, it can bind with metal ions to form stable gluconate salts, such as calcium-gluconate, potassium-gluconate, and zinc-gluconate, that are used for the uptake of metal-ion supplements.

The research team found that gluconate inhibits neonatal seizures by targeting what are known as CLC-3 chloride channels. These channels mediate a large ion current in neonatal brains but are less active in adult brains. Gluconate appears to be too large to pass through the small openings of the CLC-3 channels and therefore acts as a channel blocker.

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Friday, June 14, 2019

Immune cells play unexpected role in early tuberculosis infection

Immune cells play unexpected role in early tuberculosis infection : A class of immune cells called innate lymphoid cells (ILCs) mediates the body’s initial defense against tuberculosis (TB), may provide a new approach to developing treatments and vaccines against TB.

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3rd European Congress on Pharma and Pharmaceutical Sciences | July 24-25, 2019 | Rome, Italy

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Tuesday, June 4, 2019

Track 5: Toxicology and Immunology

Toxicology is a study that involves an understanding of chemical properties and their actions on the body but differs considerably in other areas. Toxicology is the scientific study of adverse effects that occur in living organisms due to chemicals.
It involves observing and reporting symptoms, mechanisms, detection and treatments of toxic substancesin particular, relation to the poisoning of humans. It includes environmental agents and chemical compounds found in nature, as well as pharmaceutical compounds that are synthesized for medical use by humans. These substances may produce toxic effects in living organisms including disturbance in growth patterns, discomfort, disease and death.
Immunology is the study of the Immune system that protects us from getting an infection. There are 3 main ways in which our immune system contributes to disease, the are Activation, Immunodeficiency, and Hypersensitivity.
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  • Regulatory toxicology
  • Toxicokinetics
  • Toxicologic Pathology
  • Plant toxicology
  • Emergent Contaminants
  • Medical Toxicology
  • Clinical toxicology
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Friday, May 31, 2019

Keynote Speaker – Dr. Madhuri Singhal

Prof.Dr. Madhuri Singhal is going to be a Keynote Speaker for #EuropeanPharma2019 scheduled on July 24-25, 2019 at Rome, Italy.

We feel really honored to have her presence at our esteemed conference.

Join us to hear her inspiring talk on the topic "Antimicrobial efficacy of tropical medicinal plants"

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Thursday, April 11, 2019

Collaborator of European Pharma 2019!!

PULSUS warmly welcomes all the participants, Scientists, and Delegates from the globe to join our conference "3rd European Congress on Pharma and Pharmaceutical Sciences" during July 25-26, 2019 at Rome, Italy

We are happy to announce our Collaborator for European Pharma 2019 -
British Society of Toxicological Pathology

The British Society of Toxicological Pathology (BSTP) was founded in 1985 as an organization primarily for pathologists working in the field of toxicological pathology. The BSTP is a non-profit-making organization and a Registered UK Charity. The aim of the BSTP is to advance all aspects of toxicologic and experimental pathology for pathologists, toxicologists and bioscientists though training programmes and continuing educational symposia so as to enable professional development, competence and guidance for new trainees and experienced members alike.
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Thursday, March 21, 2019

Algae could prevent limb amputation- Says British Heart Foundation

A new algae-based treatment could reduce the need for amputation in people with critical limb ischaemia, according to new research funded by the British Heart Foundation, published today in the journal npj Regenerative Medicine.

Small capsules from brown algae which hold macrophages, a type of white blood cell

Article Souce- World Pharma News

Tests in mice have shown that these algae capsules may be able to increase blood flow in the limbs where tissue has been damaged.

Scientists have been experimenting with cells as a treatment to grow arteries in the leg for years, however, these treatments have not been effective in humans. A big challenge is that many of the cells injected into the injured area die, move away to surrounding areas, or are detected as 'foreign' by the immune system and rejected.

Alginate from the cell walls of brown algae, which is mainly found in cold waters in the Northern Hemisphere, was used to form the capsules. They found that these macrophages successfully remained in the injured area, new blood vessels formed, and as a result more blood reached the damaged area.

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When? - July 25-26, 2019

Where? - Rome, Italy


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Monday, March 18, 2019

128 days to go for European Pharma 2019 conference

PULSUS presents an annual conference on Pharmaceutical Sciences titled "3rd European Congress on Pharma and Pharmaceutical Science" scheduled on July 25-26, 2019 at Rome, Italy.

This conference is specially designed to bring in expertise in the field of Pharma and Pharmaceutical sciences across the globe, for mutual sharing and enrichment of invaluable knowledge and noble work.

The main theme of the conference is “Innovations & Advancements in Pharmaceutical Sciences” which covers a wide range of important sessions.
The event focuses on the following key topics:
  • Pharmacokinetics and Pharmacodynamics
  • Pharmacovigilance and Drug Safety
  • Clinical Data Management
  • 3D Printing and Artificial Intelligence
    many more
The vision of European Pharma 2019 is to provide a comprehensive discussion on current research and development of drug discovery that will coherently help in providing better livelihood and healthier world.

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